CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

During tumor progression, circulating monocytes and macrophages are actively recruited into tumors where they alter the tumor microenvironment to accelerate tumor progression. Macrophages shift their functional phenotypes in response to various microenvironmental signals generated from tumor and stromal cells. Based on their function, macrophages are divided broadly into two categories: classic...

P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform

Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...

The Fight against Cancer

The Fight Against Cervical Cancer

Globally, cervical cancer is one of the most deadly forms of cancer affectingwomen—killingmore than 270,000 people every year. Themajority of these deaths (85%, according to theWHO) occur in developing countries. A global health priority, therefore, is to provide low-cost, highly effective cervical cancer prevention, detection, and control options to all women who need them. The human papilloma...

The Eternal Fight against Cancer

Humans have had cancer throughout documented history; hence it is no surprise that people have written about this deadly disease through ancient history. The Edwin Smith Papyrus, the oldest description of cancer, was discovered around 3000-2500 BC in Egypt describing 8 breast tumors that were eradicated by cauterization with a fire drill. As expected back then, the statement of the Egyptian wri...